昼夜节律对电子鼻呼出气体分析的影响
influence of circadian rhythm on exhaled breath profiling by electronic nose
昼夜节律对电子鼻呼出气体分析的影响
liotino v, dragonieri s, quaranta vn , carratu p, ranieri t, resta o
journal of biological regulators and homeostatic agents [01 sep 2018, 32(5):1261-1265]
abstract
electronic noses (e-noses) are a cheap and easy method for exhaled volatile organic compound (voc)-analysis which has shown its potential in several diseases. before obtaining a full validation of these instruments in clinical settings, a number of methodological issues still have to be established. we aimed to investigate a potential influence of circadian variation on voc-profile analyzed by an e-nose in healthy subjects. we enrolled 22 adults free of any known diseases. a sequence of exhaled breath samplings were performed on all participants at predetermined hours (7am, 12pm, 17pm, 23pm) and analyzed by an e-nose (cyranose 320). according to principal component analysis, significant circadian variations of the exhaled voc-profile were shown for principal component (pc) 1 and 3. in detail, pc1 and pc3 values were significantly higher in the morning compared to the afternoon and evening (for all parameters p less than 0.05). successive linear discriminant analysis confirmed the findings above. the daily variations in vocs-profile, with the peak in the morning, could be relevant for future clinical applications, especially in the choice of optimal time for sampling patients.
电子鼻是一种廉价易行的挥发性有机化合物(voc)分析工具，已在多种疾病中显示出其诊断潜力。在临床环境中对这些仪器进行全面验证之前，还必须确定一些方法问题。我们旨在研究昼夜变化对健康受试者用电子鼻分析voc曲线的潜在影响。我们招募了22名没有任何已知疾病的成年人。所有受试者在预定时间(7:00、12:00、17:00、23:00)进行呼气取样，并通过电子鼻(cyranose 320)进行分析。根据主成分分析，主成分(pc)1和3的挥发性有机化合物释放曲线的昼夜变化显著。具体来说，与下午和晚上相比，早晨的pc1和pc3值明显更高(所有参数p均小于0.05)。连续线性判别分析证实了上述发现。vocs曲线的日变化，随着早晨的峰值，可能与未来的临床应用有关，特别是在为患者选择采样时间方面。
压力变送器发生问题如何排查
CO报警器中的核心部件一氧化碳传感器
电压/电流校验仪压力测量：-100kPa ～ 1kPa
原子吸收分光光度计的9个常见故障和排除方法
赫施曼助力再生水水质中苯系物的测定
昼夜节律对电子鼻呼出气体分析的影响
测定火山灰、粉煤灰质水泥混合材试验方法水泥组分测定仪
常州排屑机的八种常见问题及解决方法
黄金吸附树脂的使用注意事项与生产流程
使用真空干燥机时应注意的问题
武汉大楚交通分析高速公路护栏的结构特性
布袋除尘器贮气包的设计方案
非标型汽车运输振动测试台
橡塑保温管的简介
外圆磨床的结构和特点
鱼类主要组织相容性复合体elisa检测试剂盒操作流程
西门子：新工艺技术帮助钢铁行业减少资源使用
液氮罐的种类
HAWE哈威NSWP2型换向阀的工作原理
水处理行业前景分析
昼夜节律对电子鼻呼出气体分析的影响
liotino v, dragonieri s, quaranta vn , carratu p, ranieri t, resta o
journal of biological regulators and homeostatic agents [01 sep 2018, 32(5):1261-1265]
abstract
electronic noses (e-noses) are a cheap and easy method for exhaled volatile organic compound (voc)-analysis which has shown its potential in several diseases. before obtaining a full validation of these instruments in clinical settings, a number of methodological issues still have to be established. we aimed to investigate a potential influence of circadian variation on voc-profile analyzed by an e-nose in healthy subjects. we enrolled 22 adults free of any known diseases. a sequence of exhaled breath samplings were performed on all participants at predetermined hours (7am, 12pm, 17pm, 23pm) and analyzed by an e-nose (cyranose 320). according to principal component analysis, significant circadian variations of the exhaled voc-profile were shown for principal component (pc) 1 and 3. in detail, pc1 and pc3 values were significantly higher in the morning compared to the afternoon and evening (for all parameters p less than 0.05). successive linear discriminant analysis confirmed the findings above. the daily variations in vocs-profile, with the peak in the morning, could be relevant for future clinical applications, especially in the choice of optimal time for sampling patients.
电子鼻是一种廉价易行的挥发性有机化合物(voc)分析工具，已在多种疾病中显示出其诊断潜力。在临床环境中对这些仪器进行全面验证之前，还必须确定一些方法问题。我们旨在研究昼夜变化对健康受试者用电子鼻分析voc曲线的潜在影响。我们招募了22名没有任何已知疾病的成年人。所有受试者在预定时间(7:00、12:00、17:00、23:00)进行呼气取样，并通过电子鼻(cyranose 320)进行分析。根据主成分分析，主成分(pc)1和3的挥发性有机化合物释放曲线的昼夜变化显著。具体来说，与下午和晚上相比，早晨的pc1和pc3值明显更高(所有参数p均小于0.05)。连续线性判别分析证实了上述发现。vocs曲线的日变化，随着早晨的峰值，可能与未来的临床应用有关，特别是在为患者选择采样时间方面。
压力变送器发生问题如何排查
CO报警器中的核心部件一氧化碳传感器
电压/电流校验仪压力测量：-100kPa ～ 1kPa
原子吸收分光光度计的9个常见故障和排除方法
赫施曼助力再生水水质中苯系物的测定
昼夜节律对电子鼻呼出气体分析的影响
测定火山灰、粉煤灰质水泥混合材试验方法水泥组分测定仪
常州排屑机的八种常见问题及解决方法
黄金吸附树脂的使用注意事项与生产流程
使用真空干燥机时应注意的问题
武汉大楚交通分析高速公路护栏的结构特性
布袋除尘器贮气包的设计方案
非标型汽车运输振动测试台
橡塑保温管的简介
外圆磨床的结构和特点
鱼类主要组织相容性复合体elisa检测试剂盒操作流程
西门子：新工艺技术帮助钢铁行业减少资源使用
液氮罐的种类
HAWE哈威NSWP2型换向阀的工作原理
水处理行业前景分析