电子鼻技术用于石棉引发呼吸疾病诊断应用研究

breath analysis in asbestos-related disorders: a review of the literature and potential future applications
电子鼻技术用于石棉引发呼吸疾病诊断应用研究
eleanor a chapman1, paul s thomas1 and deborah h yates2,3
abstract
asbestos usage was very common worldwide in the last century and continues in several countries today. several diseases occur due to asbestos exposure, including malignant tumours such as malignant mesothelioma of the pleura and lung cancer, which have a very poor prognosis. asbestos inhalation may also result in more benign conditions such as asbestosis (or pulmonary fibrosis due to asbestos), pleural plaques and pleural thickening. it is predicted that asbestos-associated mortality and morbidity will continue to increase, but methods for diagnosing asbestos-related disease are currently invasive and unsuitable for an increasingly elderly population. new non-invasive methods such as analysis of exhaled breath biomarkers e.g. exhaled nitric oxide (f(e)no), exhaled breath condensate or of exhaled volatile organic compounds could potentially be extremely useful in these conditions. this article reviews the current literature on this topic and suggests areas for their application in the future.
石棉的使用在上个世纪在世界范围内非常普遍,今天仍在几个国家继续使用。石棉暴露可导致多种疾病,包括恶性肿瘤,如胸膜恶性间皮瘤和肺癌,预后极差。吸入石棉也可能导致良性疾病,如石棉肺(或石棉引起的肺纤维化)、胸膜斑块和胸膜增厚。据预测,石棉相关的死亡率和发病率将继续增加,但目前诊断石棉相关疾病的方法是侵入性的,不适合日益老龄化的人群。新的非侵入性方法,如分析呼出的呼吸生物标志物,如呼出的一氧化氮(f(e)no)、呼出的呼吸冷凝液或呼出的挥发性有机化合物,在这些情况下可能非常有用。本文回顾了有关这一主题的现有文献,并提出了今后的应用领域。
electronic noses (cyranose 320)have been successfully used to distinguish breath samples from patients with lung cancer from control subjects, with high accuracy, specificity and sensitivity. lung cancer secondary to asbestos exposure is clinically indistinguishable from lung cancer due to other causes, so it would be expected that results in this group would be similar. however, the profile could be altered by the presence of other asbestos-related disorders such as pleural plaques or
asbestosis, and thus studies are currently evaluating the voc profile of subjects with asbestos-related disorders. however, no information is yet available in this area. the literature onlung cancer is summarized below .
电子鼻(cyranose320)已成功地用于区分肺癌患者和对照组的呼吸样本,具有较高的准确性、特异性和敏感性。由于石棉暴露引起的肺癌在临床上与其他原因引起的肺癌是不可区分的,因此这一组的结果应该是相似的。然而,其他石棉相关疾病如胸膜斑块或石棉中毒,因此研究目前正在评估与石棉相关疾病的受试者的voc特征。然而,目前还没有这方面的信息。关于癌症的文献总结如下。

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